For Healthcare Professionals Outside the US
KISQALI is indicated for the treatment of women with hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)—negative locally advanced or metastatic breast cancer in combination with an aromatase inhibitor or fulvestrant as initial endocrine-based therapy, or in women who have received prior endocrine therapy. In pre‑ or perimenopausal women, the endocrine therapy should be combined with a luteinizing hormone‑releasing hormone (LHRH) agonist.

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Dosing-with-AI
Trial-Design-MONALEESA-2

Patients were stratified by the presence of liver and/or lung metastases. The primary end point was PFS using RECIST v1.1; secondary end points included OS, ORR, QoL, and safety.

aBC, advanced breast cancer; AI, aromatase inhibitor; ORR, overall response rate; OS, overall survival; PFS, progression-free survival; QoL, quality of life; RECIST, Response Evaluation Criteria In Solid Tumors.
References: 1. KISQALI [Summary of Product Characteristics]. Novartis Pharma AG; 2019. 2. Hortobagyi G, Stemmer S, Burris H, et al. Overall survival results from the phase III MONALEESA-2 trial of postmenopausal patients with HR+/HER2− advanced breast cancer treated with endocrine therapy ± ribociclib. Presented at: European Society of Medical Oncology virtual congress. September 16-21, 2021.