Postmenopausal with AI | KISQALI® (ribociclib) Professional Site

For Healthcare Professionals Outside the US
KISQALI is indicated for the treatment of women with hormone receptor (HR)–positive, human epidermal growth factor receptor 2 (HER2)—negative locally advanced or metastatic breast cancer in combination with an aromatase inhibitor or fulvestrant as initial endocrine-based therapy, or in women who have received prior endocrine therapy. In pre‑ or perimenopausal women, the endocrine therapy should be combined with a luteinizing hormone‑releasing hormone (LHRH) agonist.

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One event of interest (hypertension) fell below the reporting threshold listed here. NA denotes not applicable, since grade 4 cough and grade 3 and 4 alopecia are not included in the National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.03.
*Four patients who were randomly assigned to the placebo group did not receive either placebo or letrozole.
†Neutropenia includes a decreased neutrophil count and granulocytopenia.
‡This category includes both anemia and a decreased hemoglobin level.

AI, aromatase inhibitor.

Reference: 1. Hortobagyi GN, Stemmer SM, Burris HA, et al. Ribociclib as first-line therapy for HR-positive, advanced breast cancer. N Engl J Med. 2016;375(18):1738-1748.

Majority of adverse events were predictable, manageable, and reversible

AI, aromatase inhibitor.

Reference: 1. Hortobagyi GN, Stemmer SM, Burris HA, et al. Ribociclib as first-line therapy for HR-positive, advanced breast cancer. N Engl J Med. 2016;375(18):1738-1748.

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